Description
Product Characteristics:
Zic1 is a C2H2 zinc finger transcription factor that controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation. Zic1 determines the cerebellar folial pattern by influencing proliferation in the external germinal layer (EGL). Zic1 can bind and transactivate the apolipoprotein E gene.This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Odd paired homolog Drosophila, Zic 1, ZIC, Zic family member 1 odd-paired Drosophila homolog, Zic family member 1, Zic protein member 1, zic1, ZIC1_HUMAN, Zinc finger protein 201, Zinc finger protein of the cerebellum 1, Zinc finger protein ZIC 1, Zinc finger protein ZIC1, ZNF 201, ZNF201.
Target Information: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]